genetic mutation

noun

plural genetic mutations
: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes
Lacking working copies of the p53 gene, cells can begin to divide without check, though several other genetic mutations are thought to be needed to foster a full-blown malignancy.Natalie Angier

Examples of genetic mutation in a Sentence

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Moving forward, researchers are eager to know if other people might have the same genetic mutation and the same blood group. Sarah Kuta, Smithsonian Magazine, 24 June 2025 However, about 85% of cases occur in women who have no family history of breast cancer, likely stemming from genetic mutations that occur because of aging, health agencies report. Angelica Stabile, FOXNews.com, 3 June 2025 While some cases may be linked to genetic mutations, many, like Candrilli’s, are not. Adaira Landry, Forbes.com, 23 May 2025 Hypopigmentation occurs when cells that produce melanin change due to genetic mutations or damage. Carrie Madormo, Rn, Health, 4 Apr. 2025 See All Example Sentences for genetic mutation

Word History

First Known Use

1915, in the meaning defined above

Time Traveler
The first known use of genetic mutation was in 1915

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Cite this Entry

“Genetic mutation.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/genetic%20mutation. Accessed 8 Jul. 2025.

Medical Definition

genetic mutation

noun
: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes
Gaucher's disease results from one of many genetic mutations that can either slow or prevent the breakdown of certain glycolipids, which accumulate in storage vesicles and eventually kill cells.Joseph Alper
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