genetic mutation

noun

plural genetic mutations

: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes

Lacking working copies of the p53 gene, cells can begin to divide without check, though several other genetic mutations are thought to be needed to foster a full-blown malignancy.

—Natalie Angier

Examples of genetic mutation in a Sentence

Recent Examples on the Web

Moving forward, researchers are eager to know if other people might have the same genetic mutation and the same blood group. —Sarah Kuta, Smithsonian Magazine, 24 June 2025

However, about 85% of cases occur in women who have no family history of breast cancer, likely stemming from genetic mutations that occur because of aging, health agencies report. —Angelica Stabile, FOXNews.com, 3 June 2025

While some cases may be linked to genetic mutations, many, like Candrilli’s, are not. —Adaira Landry, Forbes.com, 23 May 2025

Hypopigmentation occurs when cells that produce melanin change due to genetic mutations or damage. —Carrie Madormo, Rn, Health, 4 Apr. 2025

Word History

First Known Use

1915, in the meaning defined above

Rhymes for genetic mutation

• acclimatisation
• acclimatization
• acidification
• actualization
• annualization
• autocorrelation
• autoregulation
• beatification
• beneficiation
• biodegradation
• biotransformation
• bureaucratization

Medical Definition

genetic mutation

noun

: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes

Gaucher's disease results from one of many genetic mutations that can either slow or prevent the breakdown of certain glycolipids, which accumulate in storage vesicles and eventually kill cells.

—Joseph Alper